Journal of Biomedical Research and Clinical Investigation, 2020.ġ2. Carvallo, H., et al., Study of the efficacy and safety of topical ivermectin + iota-carrageenan in the prophylaxis against COVID-19 in health personnel. Carvallo, H., et al., Safety and efficacy of the combined use of ivermectin, dexamethasone, enoxaparin and aspirin against COVID 19. Camprubí, D., et al., Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients. Caly, L., et al., The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Bray, M., et al., Ivermectin and COVID-19: a report in antiviral research, widespread interest, an FDA warning, two letters to the editor and the authors' responses. Behera, P., et al., Prophylactic role of ivermectin in SARS-CoV-2 infection among healthcare workers. Babalola, O.E., et al., Ivermectin shows clinical benefits in mild to moderate COVID19: a randomised controlled double-blind, dose-response study in Lagos.
Arévalo, A.P., et al., Ivermectin reduces coronavirus infection in vivo: a mouse experimental model. European Journal of Medical Health and Sciences, 2020.Ĥ. Alam, M.T., et al., Ivermectin as pre-exposure prophylaxis for COVID-19 among healthcare providers in a selected tertiary hospital in Dhaka – an observational study. Ahmed, S., et al., A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness. Elgazzar, A., et al., Efficacy and safety of ivermectin for treatment and prophylaxis of COVID-19 pandemic. This EMA public health statement has been endorsed by the COVID-19 EMA pandemic Task Force (COVID-ETF), in light of the ongoing discussions on the use of ivermectin in the prevention and treatment of COVID-19.ġ Czechia and Slovakia, have allowed the temporary use of the medicine for COVID-19 within the remit of their national legislation.ġ. Further well-designed, randomised studies are needed to draw conclusions as to whether the product is effective and safe in the prevention and treatment of COVID-19.
Toxicity when ivermectin is used at higher than approved doses therefore cannot be excluded.ĮMA therefore concluded that use of ivermectin for prevention or treatment of COVID-19 cannot currently be recommended outside controlled clinical trials. EMA therefore concluded that the currently available evidence is not sufficient to support the use of ivermectin in COVID-19 outside clinical trials.Īlthough ivermectin is generally well tolerated at doses authorised for other indications, side effects could increase with the much higher doses that would be needed to obtain concentrations of ivermectin in the lungs that are effective against the virus. Most studies EMA reviewed were small and had additional limitations, including different dosing regimens and use of concomitant medications. Results from clinical studies were varied, with some studies showing no benefit and others reporting a potential benefit. Laboratory studies found that ivermectin could block replication of SARS-CoV-2 (the virus that causes COVID-19), but at much higher ivermectin concentrations than those achieved with the currently authorised doses. 1įollowing recent media reports and publications on the use of ivermectin, EMA reviewed the latest published evidence from laboratory studies, observational studies, clinical trials and meta-analyses.
Ivermectin medicines are not authorised for use in COVID-19 in the EU, and EMA has not received any application for such use. Ivermectin is also authorised for veterinary use for a wide range of animal species for internal and external parasites.
Ivermectin covid skin#
In the EU, ivermectin tablets are approved for treating some parasitic worm infestations while ivermectin skin preparations are approved for treating skin conditions such as rosacea. EMA has reviewed the latest evidence on the use of ivermectin for the prevention and treatment of COVID-19 and concluded that the available data do not support its use for COVID-19 outside well-designed clinical trials.
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